5-Amino-1MQ dosage
5-Amino-1MQ is a small molecule, not a peptide, that blocks the enzyme NNMT. In obese mice, 20 mg/kg injected under the skin cut body weight and fat mass without changing food intake, and a 2024 follow-up improved liver and glucose markers. There are no human trials and no registered trials. Community use is 50 to 150 mg a day as oral capsules for 4 to 8 weeks; the 50 mg vials are mostly dissolved and drunk, not injected.
Basis: animal study (Neelakantan et al. 2018, Biochemical Pharmacology, diet-induced obese mice, 11 days; dose from the related patent example). mouse dose, not scalable to a human dose by simple weight
- How often
- once or twice daily
- When
- morning, with or without food
- How long
- 4 to 8 weeks, then 4 weeks off
- Route
- oral capsule (community); subcutaneous in the mouse studies
- Storage
- powder: room temperature, dry and dark; solution: fridge, use within 2 weeks (commonly reported)
Dose ranges by source
| Range | Per | Basis | Note |
|---|---|---|---|
| 20 mg/kg subcutaneous | day | animal study (Neelakantan et al. 2018, Biochemical Pharmacology, diet-induced obese mice, 11 days; dose from the related patent example) | mouse dose, not scalable to a human dose by simple weight |
| 50 mg to 150 mg per day | day | commonly reported | oral capsules, usually 50 mg once or twice a day, 4 to 8 weeks |
5-Amino-1MQ dose to units chart
50 mg vial + 1 mL bacteriostatic water = 50 mg/mL (500 mcg per unit on a U-100 insulin syringe). 50 mg + 1 mL = 50 mg/mL, so 50 mg is the whole 1 mL = 100 units. Most people do not inject it; a 50 mg vial is one oral dose dissolved in water. There is no human injection data.
| Dose | mL | Units (U-100) | Doses per vial |
|---|---|---|---|
| 20 mcg | 0.0004 | 0.04 | 2500 |
Different vial or water? Full 50 mg + 1 mL table or set your own numbers below.
Side effects
- nausea (reported)
- headache (reported)
- sleep disruption (reported)
- long-term safety unknown
5-Amino-1MQ dosage questions
5-amino-1MQ dosage?
There is no human-tested dose. Community use is 50 to 150 mg a day by mouth, usually one 50 mg capsule once or twice a day, for 4 to 8 weeks. The mouse studies injected 20 mg/kg under the skin, which does not convert to a human capsule dose.
Do you inject 5-amino-1MQ?
Almost nobody does. It is sold as capsules or 50 mg vials that people dissolve and drink. The mice were injected, but there is no human injection data and the molecule is orally available in the 2024 mouse pharmacokinetics.
Does 5-amino-1MQ work for fat loss?
In obese mice, yes: less weight and fat with the same food intake. In humans, unknown. No trial has been run or registered, so any human result is anecdote.
Is 5-amino-1MQ a peptide?
No. It is a quinolinium small molecule sold by peptide suppliers. That matters for testing: a standard peptide HPLC purity certificate does not apply the same way.
Sources
- Neelakantan H et al., Biochem Pharmacol 2018, Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice (PubMed 29155147)
- Babula JA, Neelakantan H et al., Diabetes Obes Metab 2024, Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction (5A1MQ in diet-induced obese mice, IV, oral and subcutaneous PK)
- Peptide Protocol Wiki, 5-Amino-1MQ research summary (no human trials)
Brands we recommend for 5-Amino-1MQ. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.
- Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
- Core Peptides long track record, public certificates, wide catalog
- Ascension Peptides public third-party testing, clear pricing
This page is an educational summary of published labels, trials and commonly reported use. It is not medical advice and does not replace a clinician.