anti-inflammatory tripeptide (alpha-MSH fragment) · studied for gut inflammation and colitis in mice, skin inflammation, wound models

KPV dosage

KPV is the last three amino acids of alpha-MSH. In mice it calmed two models of colitis and reduced gut inflammation markers, and cell work shows it enters gut cells through the PepT1 transporter, which is why oral use is discussed. There are no human trials and no human dose. Community use is 200 to 500 mcg subcutaneously once or twice a day, or oral capsules in the low milligram range, for 2 to 6 weeks.

By the Peptide Calculations editors · Updated 2026-10-19

200 mcg to 500 mcg per injectionper injection

Basis: commonly reported. once or twice daily; 250 mcg twice a day is the common split

How often: once or twice daily
When: any time; oral forms are taken before meals
How long: 2 to 6 weeks, then reassess
Route: subcutaneous (abdomen); oral capsules also sold; topical for skin
Storage: lyophilized: fridge or freezer; reconstituted: fridge, use within 4 weeks (commonly reported)

Dose ranges by source

Range	Per	Basis	Note
200 mcg to 500 mcg per injection	injection	commonly reported	once or twice daily; 250 mcg twice a day is the common split
500 mcg to 1,000 mcg per day	day	commonly reported	upper range used during gut flares, 2 to 4 weeks

KPV dose to units chart

5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL (25 mcg per unit on a U-100 insulin syringe). 5 mg + 2 mL = 2.5 mg/mL, so 250 mcg = 0.1 mL = 10 units and 500 mcg = 20 units. A 10 mg vial + 2 mL doubles the strength: 250 mcg = 5 units.

Dose	mL	Units (U-100)	Doses per vial
200 mcg	0.08	8	25
250 mcg	0.1	10	20
300 mcg	0.12	12	16
350 mcg	0.14	14	14
450 mcg	0.18	18	11
500 mcg	0.2	20	10

Different vial or water? Full 5 mg + 2 mL table or set your own numbers below.

Commonly stacked with

LL-37 0.5 mg/mL to 1.6 mg/mL topical, twice weekly
KLOW blend 2 mg to 4 mg of blend per injection (10 to 20 units at 20 mg/mL)

Side effects

injection site redness
few side effects reported
mild fatigue (reported)

Before you start. Human dosing is not established. Every efficacy result is from mice or cell culture, the 2008 colitis study being the main one. The microgram community dose is an extrapolation, not a scaled animal dose. Not medical advice. Talk to a clinician and start low.

KPV dosage questions

What is the KPV peptide dosage?

There is no human-tested dose. Community use is 200 to 500 mcg subcutaneously once or twice a day for 2 to 6 weeks, with 250 mcg twice daily the most common split. Oral capsules are usually in the low milligram range.

How many units of KPV is 250 mcg?

With 5 mg in 2 mL (2.5 mg/mL), 250 mcg is 10 units. With 10 mg in 2 mL it is 5 units, so use 4 mL on a 10 mg vial if you want 10-unit draws.

Can KPV be taken orally?

Yes, it is sold as capsules and mouse work shows it is absorbed by gut cells through the PepT1 transporter. Oral doses people use are higher than injected ones because less reaches the bloodstream. No human study compares the routes.

Is KPV good for gut inflammation?

In mice with chemically induced colitis it sped recovery and reduced inflammation markers. That is the whole evidence base. People with inflammatory bowel conditions report trying it alongside, not instead of, their treatment.

Sources

Brands we recommend for KPV. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.

Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
Core Peptides long track record, public certificates, wide catalog
Ascension Peptides public third-party testing, clear pricing

This page is an educational summary of published labels, trials and commonly reported use. It is not medical advice and does not replace a clinician.