MOTS-c calculator
MOTS-c is a 16 amino acid peptide encoded in mitochondrial DNA. In the 2015 Cell Metabolism paper, mice given 0.5 mg/kg a day for 8 weeks were protected from diet-induced obesity and insulin resistance, and 5 mg/kg for a week improved glucose handling.
- Frequency
- two to three times weekly
- Timing
- morning or before exercise, by user report
- Cycle
- 4 to 6 weeks, repeated 2 to 4 times a year, with breaks
- Route
- subcutaneous, abdomen
- Easy mix
- 10 mg + 1 mL = 10 mg/mL, so 5 mg = 0.5 mL = 50 units; 2.5 mg = 25 units, 10 mg = 100 units (a full syringe). With 2 mL of water, 5 mg becomes 100 units.
MOTS-c units chart
10 mg vial. Rows are doses; columns show the units to draw on a U-100 syringe at each water volume.
| Dose | mL | U-100 units | Doses per vial |
|---|---|---|---|
| 100 mcg | 0.01 | 1 | 100 |
| 200 mcg | 0.02 | 2 | 50 |
| 250 mcg | 0.025 | 2.5 | 40 |
| 500 mcg | 0.05 | 5 | 20 |
| 1 mg | 0.1 | 10 | 10 |
| 2 mg | 0.2 | 20 | 5 |
| 2.5 mg | 0.25 | 25 | 4 |
| 5 mg | 0.5 | 50 | 2 |
| 10 mg | 1 | 100 | 1 |
Other mixes: 10 mg + 2 mL · 10 mg + 3 mL
About the MOTS-c math
MOTS-c is a 16-amino-acid peptide whose sequence is encoded in mitochondrial DNA. Research listings are almost always 10 mg vials of lyophilized powder. With whole-milligram example draws, the math can run into syringe capacity. A 10 mg vial with 2 mL of bacteriostatic water is 5 mg/mL, or 5,000 mcg/mL. A 2 mg draw is 0.4 mL, or 40 units on a U-100 syringe, and the vial holds five draws. A 5 mg draw at the same concentration is 1 mL, or 100 units, the whole barrel of a 1 mL syringe, and the vial holds only two. With 1 mL in the vial the concentration is 10 mg/mL, so 5 mg is 0.5 mL, or 50 units, and 2 mg is 20 units. With 4 mL it is 2.5 mg/mL and a 5 mg draw becomes 2 mL, more than any U-100 syringe holds, so it would have to be split into two 100 unit draws. Picking a small solvent volume keeps large draws inside one barrel.
MOTS-c questions
How much MOTS-c should I take?
There is no human dose. The commonly reported protocol is 5 to 10 mg under the skin two to three times a week for 4 to 6 weeks, with some people doing 10 mg once a week. On a 10 mg vial in 1 mL, 5 mg is 50 units.
How do you reconstitute 10 mg of MOTS-c?
Add 1 mL of bacteriostatic water for 10 mg/mL, so 5 mg is 50 units and 10 mg is a full 100 unit syringe. With 2 mL, 5 mg becomes a full syringe. Because the doses are large, a 1 mL reconstitution keeps the injection volume manageable.
How many units is 2 mg of MOTS-c at 10 mg in 2 mL?
10 mg divided by 2 mL is 5 mg/mL. 2 mg divided by 5 mg/mL is 0.4 mL, which is 40 units on a U-100 syringe. The vial holds 5 such draws.
How much bacteriostatic water for a 10 mg vial of MOTS-c?
Any volume the vial holds. 1 mL gives 10 mg/mL, 2 mL gives 5 mg/mL and 3 mL gives 3.33 mg/mL (rounded). A 5 mg draw is 50 units, 100 units or 150 units at those concentrations, and 150 units is more than one U-100 syringe holds.
How many 5 mg draws are in a 10 mg vial of MOTS-c?
10 divided by 5 is 2 draws. The solvent volume sets how big each draw is: 0.5 mL (50 units) with 1 mL in the vial, or 1 mL (100 units) with 2 mL in the vial.
Brands we recommend for MOTS-c. We are independent and have no affiliation with any brand: no affiliate links, no referral codes, no paid placements. These are the suppliers whose testing and certificates hold up when we check them.
- Licensed Peptides two accredited labs on every lot, certificates public, card and Apple Pay checkout
- Core Peptides long track record, public certificates, wide catalog
- Ascension Peptides public third-party testing, clear pricing